The Atletico Madrid boss has insisted that he is not afraid of the two teams and believes that media coverage makes others apprehensive when facing them.
The Argentine feels that the amount of coverage dedicated to the Clasico clubs creates an element of fear around them among domestic teams. However, Simeone believes he sees through the hyperbole surrounding the two teams and would not mind locking horns with them more often.
"It's better for us. In the sports papers, 10 pages are dedicated to Madrid and another 10 to Barca and if they win 4-0, it's as though they won 16-0 because they constantly repeat the highlights," he told Ole.
"That creates a situation of fear and so when you have to play against them, you're almost losing from the start. For foreign teams it's a bit different, meeting Madrid or Barca motivates them as they are less affected by the media hype. If it was up to me, I'd play against them every week."
Simeone went on to outline his ambition to instill a strong mentality in his team, which will help it challenge Real Madrid and Barca for titles.
"We want to build a team which shows commitment," he continued. "That is a very big word to use and I mean it in the sense of being committed to play, to run, to train, respect your rival, understand the intelligence that lies behind the game.
"At Atletico, I think we are achieving that and it's fantastic to see a kind of commitment that few people have in life. We have a very specific way of working. We know that, as a team, we are dangerous and competitive. We also know that, over 40 weeks, Real Madrid and Barca will be streets ahead of us but in the day-to-day, we feel very close to them."