La Liga's bottom club has axed its boss, with the weekend's 2-2 draw against Rayo Vallecano being deemed the final straw.
Real Betis has sacked coach Pepe Mel with the club sitting bottom of the Primera Division after 15 games.
Mel had been with the club since 2010, taking it back to the top flight in the 2010-11 season before securing a Europa League spot after finishing an impressive seventh last campaign.
However, while Betis sits second in Group I and well placed to progress in the continental competition, its domestic form has been terrible in this campaign.
Mel leaves the club rock-bottom in the table, having won just twice from 15 games and failing to win any of the last eight league matches, including a painful 4-0 derby defeat against Sevilla.
In a statement on their official website, Betis said the decision was because of the "delicate situation on the field as well as the need to change the dynamics of results" but thanked the coach for his time in charge, where he "led us from the Segunda to the Europa League."
Roberto Rios and David Gomez, members of Mel's backroom staff, have also left the club.