Real Madrid was forced to withdraw Cristiano Ronaldo during its 5-0 Liga win over Almeria after the Portugal star picked up an injury in the early stages of the second half.
The 28-year-old appeared to pull up in discomfort after he burst down the left wing before stretching to fire in a cross with his left foot.
The Portugal captain then signaled to the bench he wished to be withdrawn due to a problem with his left thigh, with Jese Rodriguez replacing him.
Ronaldo had put his side 1-0 up in the first half prior to being forced off with the knock.
Early reports suggest the injury is not serious, with Ronaldo able to walk from the pitch and down the touchline without assistance.
The former Manchester United man joins fellow Ballon d'Or favorites Lionel Messi and Franck Ribery on the treatment table, with Messi likely to be out until the new year with a hamstring problem while Ribery suffered a minor fracture to a rib while on international duty with France.