The Spaniard says that Los Blancos would welcome the Wales winger with open arms at the Santiago Bernabeu, saying he would give coach Carlo Ancelotti a welcome selection headache.
Los Blancos have already confirmed their interest in the Tottenham winger, but have thus far refused to meet the Premier League outfit's asking price of 114 million euros.
There has been also been some debate over whether Madrid actually needs Bale, but Isco feels that the Welshman would represent a most welcome selection headache for Ancelotti.
"If he comes, it would a problem for the coach, but a blessed problem," Isco told reporters at a press conference on Friday. "I think what everybody thinks [about him]: That he is a really great player. So, we would welcome him as everyone else has been welcomed [this summer]."
Isco is one of Madrid's most recent arrivals, having joined from Malaga for a reported 30 million euros, and he believes he can thrive at the Bernabeu under Ancelotti's tutelage.
"He's a coach who is always speaking with you," Isco said. "He is very close to the players and his philosophy is perfect for Madrid.
"The coach asks for possession, good judgment, creativity and high pressing. It's a style that suits players who like to play. We're going to see an attractive Madrid that will do great things.
"We want to do well in all competitions, not just the Champions League. We want to win everything."
Isco admitted, though, that he faces a difficult task in nailing down a regular berth in the Madrid starting lineup.
"I will just try to do my job," Isco said. "The adaptation for me has been quick and easy. I'm delighted to be here and eager to do well.
"It's true that at Malaga I played every game as a starter, but here at Madrid, they give nothing away.
"I hope to play a lot and I hope to play on Sunday [in Madrid's Liga opener against Betis] but the coach has the final say."
Isco, who has been capped once at senior level by Spain, played a key role in the country's triumph at this summer's Under-21 European Championship.