The Blancos president called a press conference to insist that there is no truth in the report claiming the squad had demanded the exit of its coach in the summer
Reports from Spain earlier on Thursday suggested that the Madrid squad, led by Iker Casillas and Sergio Ramos, had told Perez to choose between the manager and the players during a meeting on Tuesday.
"I break my rule not to speak to the press about the club's day-by-day business due to the seriousness of the allegations published by Marca," Perez said at a press conference.
"I'm not here to talk about Iker, only to deny the information that has come out this morning. I haven't spoken to Mourinho, I came here of my own accord. They cannot play with an institution like Real Madrid.
"It is absolutely false that the captains said anything negative about the coach. No ultimatum was issued by Casillas or Ramos. The level of responsibility of the captains is incompatible with this information.
"The information published today [Thursday] is a pure lie, and it's a serious attack against the club. I have a lot of respect for the press and I always listen to criticism, regardless of whether I think it's fair or not.
"But there are limits that must be respected. This is a serious matter. It is not a typical daily rumor, on who we sign or who we dismiss, It's about ethics."
Mourinho already voiced his dismay with the way he has been treated in the press earlier this week, claiming that people are trying to create controversies that do not exist.
Despite Perez's denial, Marca has stood by its story.