The 27-year-old has distanced himself from the Barcelona forward, saying the two Liga stars are nothing more than congenial with one another.
The pair have been painted as fierce rivals in recent years, with both players competing for the same club and individual honors. Even though he admits they are not close, Ronaldo is adamant there are no issues between the two of them and expressed his respect for the Barcelona man.
"He [Lionel Messi] is a great player," Ronaldo told beIN sport. "I have a professional relationship [with him] like I have with other players. I'm not friends with him, because we don't share the same dressing room. I respect him like a professional. We're not real friends, just friends through our profession.
"There are no issues between the two of us. It's [issues being created] not just now, its been the same for the last five years. I can't control it."
Ronaldo even went to the extent of saying that he could co-exist with Messi if the two played on the same team, something that he acknowledged was an obvious longshot.
"I could perfectly play with Messi if he signs with Real Madrid, but that's very difficult," Ronaldo said.
Neither of the Ballon d'Or candidates found the back of the net on Saturday as Los Blancos recorded a comfortable 4-0 win over Zaragoza, while the Blaugrana saw off Celta Vigo 3-1.