The Atleti coach was upset with the final score but was the first to admit that his side could not live with the sheer dominance of the champion and its five-goal performance.
The capital outfit failed to exert any kind of threat on Pep Guardiola's side and paid the price for its wrong approach to proceedings by being thrashed in Catalunya, courtesy of a Lionel Messi hat-trick, plus a strike from David Villa and an own-goal from Miranda.
Manzano feels there was only one winner in the battle for possession.
"We faced a team in Barcelona that is currently settling into a rhythm," he said. "They have great players that offer tactical variety.
"It is unlikely that any team in the world would be able to win the majority of possession - it is physically impossible. To win here on those conditions, you'd have to have the performance of the century."
However, despite losing in such convincing fashion, Manzano did express his unhappiness at going down to such an unflattering scoreline.
"I'm a little angry [with the score], but I admit that this is one of the best teams of recent times," he said.
Manzano reserved empathy for big-money signing Falcao, whose display was outshone by that of his Argentine counterpart.
"Falcao has been in the gray, like the whole team, but there was not even a chance [in this game] to show how good a player Falcao is."
Atletico Madrid drops down to seventh in the Primera Division table, and will strive to get back to winning ways on Thursday, when it faces Rennes in the Europa League.