With next week's Champions League final in mind, Lionel Messi, Xavi, Andres Iniesta, Carlos Puyol, Gerard Pique, David Villa have all been left out of the squad completely.
Seydou Keita, Jonathan Dos Santos and Javier Mascherano all drop the the bench after last week's 0-0 draw against Deportivo with Maxwell, Sergi Roberto and Adriano all coming into the starting line-up.
The makeshift line-up will be looking to impress Guardiola ahead of Europe's showcase event against Manchester United next Saturday.
Malaga starting XI: Cabellero; Gamez, Kris, Weligton, Eliseu; Apono, Camacho; Fernandez, Maresca, Duda; Juanmi
Substitutes: Portillo, Silva, Gaspar, Fernando, Recio, Arnau, Rosario
Barcelona starting XI: Pinto; Bartra, Fontas, Abidal, Maxwell; Adriano, Thiago, Sergi Roberto; Afellay, Jeffren, Bojan
Substitutes: Pedro, Keita, Mascherano, Oier, Dos Santos, Busquets, Alves