The Spain international goalkeeper is confident his Argentine teammate can become revered in Naples.
The legendary Argentine led the Partenopei to two Serie A titles during a seven-year spell at the club from 1984 to 1991.
Higuain, who moved to the San Paolo from Real Madrid this summer, cited his compatriot as a source of inspiration, and Reina feels his teammate can become revered by fans.
"You can breathe football here, it's almost like a religion," he told Marca. "The god is obviously Maradaona and will be for many years. In any restaurant in Naples you can see souvenirs of him, from shirts to photos.
"I hope the same can happen with Higuain. He's the idol of the moment."
Reina, who moved to the club this summer on loan from Liverpool, went on to outline his ambition to win the Serie A title this year, but acknowledged the threats that Roma and Juventus pose.
"The idea this year is to win the Scudetto. Juventus are the reigning champions of Italy and are used to playing in the Champions Leauge, while Roma are doing very well and don't have any other cups.
"I don't know what might happen in the city if we win the title. The people are very similar to those in the south of Spain. There's certainly no lack of enthusiasm and passion. Playing in the San Paolo is extraordinary."