The Blucerchiati find themselves in 14th place in Serie A, just three points above the relegation zone, and the club has not won in its last three league games. Coach Ciro Ferrara paid the price for the club's current situation and was shown the door on Monday, and Sampdoria has acted quickly to bring in Rossi.
Sampdoria has also parted ways with sporting director Pasquale Sensibile, who will be replaced by Carlo Osti.
During his 22-year coaching career, the 52-year-old Rossi has led 10 teams, winning the Coppa Italia with Lazio in 2009.
Rossi has been without a team since he was dismissed by Fiorentina earlier this year for attacking Adem Ljajic during a 2-0 loss against Novara, and he had to endure a three-month ban from the game for his actions.
Follow GOAL.COM on