The 24-year-old has battled an abdominal problem for five months and has not featured at all this season under new boss Mauricio Pochettino.
The England international has yet to feature under new boss Mauricio Pochettino, with Spurs forced to send the defender for an operation after the injury persisted.
Tottenham had initially been optimistic that Walker would be able to shake off the injury without resorting to surgery. No date has been given for his return to action.
"Kyle is good some days, on other days he has a bad feeling," said Pochettino in August. "We believe he may recover soon, but we need to be calm with him because it is an injury that he has had for five months."
Eric Dier has filled in for Walker during the 24-year-old's absence from the first team after the club's other right back, Kyle Naughton, got sent off against West Ham in the first half of the opening game of the season.
The North Londoners also agreed to a deal to sign U.S. right back DeAndre Yedlin, who will join the squad in January after completing the MLS season with the Seattle Sounders.