The Argentine has admitted his admiration for the Mexico international, whose future at Old Trafford remains unclear, with Louis van Gaal reluctant to be drawn on the issue.
Diego Simeone believes Manchester United striker Javier Hernandez represents a "great option" for Atletico Madrid as the club looks to bolster its attack ahead of the new season.
Hernandez moved to Old Trafford in the summer of 2010 but has failed to establish himself as anything more than an impact substitute, starting just six Premier League games last season.
Former United captain Nemanja Vidic this week urged his new club Inter to make a move for the Mexican frontman, though Atletico is also hoping to fill the attacking void left by the departures of Diego Costa and David Villa.
And while Simeone - who currently has Mario Mandzukic as the only recognized striker in his squad - would not confirm he will make a move for the 26-year-old, he refused to rule it out.
"We speak to the sporting directors, we gave them the ideas on the type of players we want and then they get the players," the Argentine told reporters.
"With Javier Hernandez and plenty of other great players, anything is possible. We can't close the door to anyone until the transfer window closes.
"He is a vertical player, great in one on one situations, he's a great option for any team."
New United boss Louis van Gaal gave Hernandez a 13-minute cameo in Wednesday's International Champions Cup penalty win over Inter, but could not provide any guarantees over the player's future.
"That I cannot answer," the Dutchman insisted after the match. "He is a player of Manchester United at this moment."
The striker himself was similarly unwilling to discuss the issue. “I don’t know what’s going to happen, only God knows,” he told reporters. “I just have to keep working.”