The Netherlands coach has signed a three-year contract to take over following the World Cup, with Ryan Giggs tabbed as his assistant manager.
Manchester United has appointed Louis van Gaal as its new manager on a three-year contract.
The Dutchman, who has been linked with the position since David Moyes was relieved of his duties in April, will assume control of the Old Trafford outfit after leading his country at the 2014 FIFA World Cup in Brazil.
Ryan Giggs, who took over as interim manager following Moyes' departure, will be Van Gaal's No. 2, while Frans Hoek and Marcel Bout will join United as assistant coaches.
In a statement published on United's official website, Van Gaal said: "It was always a wish for me to work in the Premier League. To work as a manager for Manchester United, the biggest club in the world, makes me very proud.
"I have managed in games at Old Trafford before and know what an incredible arena Old Trafford is and how passionate and knowledgeable the fans are. The club has big ambitions — I too have big ambitions. Together I'm sure we will make history."
Van Gaal's distinguished coaching career has seen him win domestic titles in his native Netherlands, Spain and Germany with Ajax, Barcelona and Bayern Munich respectively, as well overseeing Ajax's UEFA Champions League victory in 1994-95.
The 62-year-old will now be tasked with turning United's fortunes around following Moyes' ill-fated 10-month spell at the helm, which resulted in the club relinquishing its Premier League title and failing to qualify for next season's Champions League.
Ed Woodward, the club's executive vice chairman, hailed the capture of Van Gaal as a major coup.
"In Louis van Gaal, we have secured the services of one of the outstanding managers in the game today," said Woodward. "He has achieved many things in his career to date and Old Trafford provides him with a fitting stage on which to write new chapters in the Manchester United story. Everyone is very excited about this new phase in the club's history. His track record of success in winning leagues and cups across Europe throughout his career makes him the perfect choice for us."