The England international is a doubt for Manchester United's home finale against Hull City and may be done for the season.
Wayne Rooney could miss Manchester United's final home game of the season against Hull City as he is suffering from illness and an injury.
The England striker sat out Saturday's 1-0 defeat against Sunderland as he has been hampered by illness as well as a hamstring problem.
United interim manager Ryan Giggs revealed on the eve of Tuesday's Premier League clash with Steve Bruce's side that his leading scorer may have played his last game of the campaign at Old Trafford.
"Wayne is probably struggling for the game," the former Wales international told MUTV on Monday: "He's not quite recovered. We'll continue to monitor him."
Giggs, who is considering selecting himself to play against Hull, also said Jonny Evans is not expected to feature in the final two games of the season because of a calf injury.
There is more positive news of fellow defender Rafael da Silva, who is set to be back in contention to face the FA Cup finalists and Southampton on the final day.
"Rafa has trained in the last few days and looks good," he said. "He could be involved in the remaining two games."
United could still climb into sixth place - and UEFA Europa League qualification - if it wins both games and Tottenham loses to Aston Villa on Sunday.