Alongside the Hillsborough Family Support Group, Reds players past and present, including those playing on the day of the tragedy, will pay their respects to the 96 fans who were killed in a crush on April 15, 1989.
Across Merseyside, bells will be rung at the time at which the club's FA Cup game with Nottingham Forest was halted on the day, with a minute of silence then asked to be observed.
In the backdrop of the memorial are fresh inquests into the truth behind the disaster, a process that began in March to re-evaluate each death after verdicts of accidental death were quashed as a result of an independent report in 2012.
The new inquest continues in Warrington and is expected to take a full year to hear all available evidence.
There were tributes across English football on Friday, Saturday and Sunday as all games kicked off seven minutes later than usual and fans all over the country given a chance to pay their respects.