The Netherlands icon claims the Chelsea boss will quickly lose the support of the dressing room as he is simply concerned with short-term results.
The Blues boss has repeatedly stated his side cannot be considered among the Premier League title challengers this season - despite sitting second in the table - and branded his players' defending as "ridiculous" following the 3-1 Champions League quarterfinal first leg defeat to Paris Saint-Germain.
Cruyff has slammed the Portuguese for his focus on short-term results at the expense of squad harmony and claims he will quickly lose the support of the dressing room at Stamford Bridge - just as he did at Real Madrid.
"PSG have a strong team with some great players. Chelsea have some great players as well, but Mourinho seems to disagree," he told De Telegraaf. "It's always the same with him. When things are going well, it's the result of his good work, but the players are to blame when things are going badly. He already lost the dressing room at Real Madrid because of that and I can see the same happen at Chelsea.
"The problem with Mourinho is that he only cares about results. The result is more important than his players. He always thinks short-term, and that's simply not my thing."
Chelsea takes on PSG in the second leg of their Champions League tie at Stamford Bridge on Tuesday.