Goals from Toni Kroos and Thomas Muller gave Pep Guardiola’s side the advantage ahead of Tuesday’s second-leg at the Allianz Arena.
"The way to win is to produce a top-level performance and turn up with quality and belief," he told reporters. "History is important in our belief. We know we can do it, because we have already done it. It is a possible task, that is the most important thing. My team has quality and ambition.
"We know that we have to attack, but we also know we have to defend. We must find the right balance. The statistics are against us, but we have won 5-1 at Inter, we have won everywhere in Europe."
Arsenal will be without first-choice goalkeeper Wojciech Szczesny for the clash after he was sent off at the Emirates, with Wenger revealing Kieran Gibbs would also be missing - although Laurent Koscielny is back in the squad.
"I hope tomorrow we get a fair chance to play 11 v 11 men until the end," he said. "We have had a few good nights in Europe but [if we win tomorrow] it would be absolutely great. When you come to this stadium, you don't need anything else. Your motivation levels are already very high.
"We scored two late goals against Everton, so we do not need to be nervous or impatient."