After losing its last two games at Old Trafford, the champion hosts a Hammers side fresh from booking a place in the Capital One Cup final with victory over Tottenham.West Ham manager Sam Allardyce urged his players to capitalize on any frailties in the Manchester United squad ahead of Saturday's showdown.
David Moyes' men have lost three home matches in the Premier League this term, including back-to-back 1-0 defeats to Everton and Newcastle United in their previous two outings on home turf.
The reigning champion has not lost three successive home league encounters since the 1978-79 season, and Allardyce called for his side to match the hosts' intensity and end its own winless run in the top flight.
"Looking back at Manchester United's history when was the last time that Manchester United lost three home games on the trot?" he told reporters. "What will the odds be for that? It's not what Manchester United or David Moyes wants to do or the players in fact. On that basis, knowing Manchester United players, their desire and determination to win that game will be greater against us.
"That will focus them even more and make sure that when they come off they've beat us. We have to make sure we match their desire and determination and the tactical organisation we showed against Tottenham.
"The key element will be, if you get a chance try and score, see if there's any frailties that may come out in Manchester United.
"I expect a tough match and I expect Manchester United to make sure they go all out to win. In our position I expect us to go and play our best within the tactical structure that we need to."
Midfielder Ravel Morrison could be set to feature against his former club, and Allardyce warned the 20-year-old not to play as an individual.
"He probably would [have a point to prove] if selected," Allardyce continued. "My concern is that if he is going to play, if I do select him, then don't try and win the game by yourself.
"This is a team game and if you want to win it play as a team, not as an individual."