A narrow loss at Old Trafford earlier this season has given the Potters manager reason to be confident ahead of Wednesday's quarterfinal clash at the Britannia Stadium.
Hughes is preparing his side for a quarterfinal clash with David Moyes' men at the Britannia Stadium on Wednesday, with the club looking for its best showing in the competition since lifting the trophy in 1972.
Late strikes from Wayne Rooney and Chicharito secured a narrow 3-2 victory for United earlier in the season and Hughes feels that showing proves Stoke cause a surprise and reach the final four.
"We will take confidence from the fact that we performed so well at Old Trafford earlier in the season," he told reporters. "We scored two very good goals and were unfortunate not to see the game out. Hopefully we can do this on Wednesday and secure ourselves a passage into the next stage."
However, despite his confidence, Hughes knows it won't be easy for his side.
"It will be a tough game though, because United are United. They have world class players, they had a good result and performance at Villa on Sunday so they will be hoping to follow that up with another good result against us," he said. "It is down to us to stop them though. We know that if we play to our maximum we have a real chance of winning the game.
"There are a lot of games coming up and I am mindful of that, but we want to stay in the competition, because if we come through this tie then we are in the last four - and from there on in, anything is possible."
Stoke heads into the fixture in good form with a 4-0 defeat at Everton its only loss in eight matches across all competitions, and Hughes believes the side is constantly improving.
"We have suffered one defeat in eight, in all competitions so we are pleased with that. We are progressing well, we are improving all of the time too," he said. "We have a decent defensive record - six or seven clean sheets which are very satisfying too. There are a lot of positives to be taken from the past few weeks, Everton aside of course."