Kevin Nolan begins his three-match ban and Stewart Downing is sidelined with a leg injury, but Ravel Morrison returns from suspension to face Gus Poyet's side.
The London club was consigned to a 4-1 hammering at Liverpool last weekend and has now lost four of its last five top-flight matches. That dismal run has left it languishing perilously above the relegation zone, level with Fulham and Crystal Palace - 18th and 19th, respectively - and five points clear of Saturday's opponents.
But despite Sunderland picking up just two points on its travels in the Premier League this season, Allardyce is not playing down the importance of his side's encounter with Gus Poyet's team.
He said: "It's a critical game for both teams. Both teams need to win and, listening to Gus' quotes, that's their objective [too]. Every team in the Premier League can be difficult to break down and most games are decided by a bit of luck or mistakes that you make. We need all the lads that are available to step up to the plate and try and repeat the Fulham performance and get the same result."
Allardyce will have to do without skipper Kevin Nolan, who starts a three-match ban following his red card at Anfield, but fellow midfielder Ravel Morrison returns from suspension. Defender James Tomkins (hamstring) will undergo a fitness test ahead of the match but Allardyce expects James Collins and Guy Demel to be available despite being unwell this week.
Stewart Downing (leg), Winston Reid (ankle), Andy Carroll (foot), Mladen Petric (calf), and Ricardo Vaz Te (shoulder) are definitely out.
Sunderland is rooted at the foot of the table with only eight points from 15 games and Tottenham condemned it to a third defeat in four last weekend. Poyet, who was appointed as Paolo Di Canio's replacement Oct. 8, is eager to secure Sunderland’s first away win of the season at Upton Park.
"We know what we are coming up against and how difficult it will be," he told the club's official website. "We need to stand up and do the right things all the time, be very strong as a group as well as being brave on the ball and making things difficult for them. Then, you always have a chance to win. We need to start winning games and we’ve got another opportunity on Saturday."
Poyet will be hoping Carlos Cuellar (hip) is available for the trip to London, while goalkeeper Keiren Westwood (shoulder) remains doubtful.