The ex-Chelsea trainer has expressed his respect for the Frenchman as he prepares to pit his Partenopei side against the Gunners in a European clash at the San Paolo.
The Gunners face the Partenopei in a crucial Champions League showdown Wednesday, and the former Chelsea boss has been impressed with the north Londoners' form this season.
The Spaniard feels that Arsenal has a great chance of lifting the Premier League trophy for the first time in 10 years but is still hopeful of leading Napoli to victory in a match that it must win by three goals in order to guarantee qualification for the last 16.
"This could be the year they win the league," Benitez told reporters. "For me Wenger is the best coach in the Premier League and knows what his team must do. Arsenal will try to control possession and hit us with counterattacks. We have to do our thing, focus on ourselves and not on them. In modern football everyone knows the quality of their rivals. Arsenal is a very strong side, we know, but we will try. My team have to give 100 percent.
"My players know how important this game is and they have all trained really well. We have nothing to lose. For us, to play at home gives us an added strength. We were unlucky to be placed in such a difficult group but, for me, it's better to experience these games rather than watch them on TV."
Napoli was vanquished 2-0 when it visited the Emirates Stadium, but Partenopei forward Goran Pandev is confident that with star striker Gonzalo Higuain in their ranks they can do better at home.
"We want to cause trouble for the English team," the Macedonia international said. "We didn't do well in the first game and we want to make up for that. It's easy when you're playing alongside Higuain. I'm on good form and that has given me confidence. We know that it will be a very difficult game but we have prepared well and we have had an excellent Champions League campaign so far.
"It's important that we don't rush things. We know how good Arsenal are and we need to remember everything that the coach has told us."