Villas-Boas welcomes the Magpies to White Hart Lane where he is searching for a home win to maintain Tottenham's strong start to the season and keep pace with league leaders Arsenal.
Newcastle has not won at Tottenham since 2008 when it cruised to a 4-1 triumph, but Villas-Boas believes it will provide a sterner test now it enters off the back of a 2-0 victory against Chelsea on Saturday.
"They come here with a victory, the highest morale-boosting victory possible and they will come here full of motivation, and it won't be in any way easy for us," he told reporters. "They are now picking up great results. They are always a team that want to be in the competition for the teams that qualify for Europe. That is probably their expectancy given the investment they do every year.
"We just have to make sure we are up to our level, we weren't for example in the game against West Ham, we hope to be solid and create as much as we can. Alan is a manager who prepares well for the games so it won't be easy for us."