The Blues have 48 hours to recover from their clash with Manchester City before traveling to the Emirates Stadium, and their manager feels a number of stars will have to sit out.
While Arsenal defeated bottom-of-the-table Crystal Palace 2-0 on Saturday, Chelsea will head to the Emirates Stadium a little more than 48 hours after securing a dramatic 2-1 win over Manchester City.
As a result, Mourinho feels unable to select a number of his leading stars and suggested the fourth-round match has lost some of its potential luster, aiming his frustration at those who made the decision for a Tuesday game.
"We are going to give the game that the people that put the game on Tuesday wants," he said. "If they want a big game, we cannot give the big game. If they want the players that were playing [on Sunday], we cannot give them that.
"If they want Arsenal to win a trophy, that's a help. If they want a big game between two big teams in London, they should put the game on Wednesday and not on Tuesday."
Mourinho is expected to select a lineup featuring first-team squad members who did not start against City, stating that a youth-team game Saturday morning leaves him wary of lumbering the club's young players with an excessive workload.
"It is not the plan because we have to also respect our fans," he said when asked if he would pick a virtual youth team. "We have to protect our players. We cannot put our players playing in October two matches in the space of three days. They played [on Saturday] at 12:30, so [that is] two-and-a-half days to prepare.
"I hope [the soccer authorities] all enjoy. We are going to try to do our job and we will do our job the best we can."