Hodgson’s men currently top Group H with 19 points – one ahead of second-placed Ukraine which travels to San Marino, a side that has never won a qualifier.
Should the Three Lions fail to win and Ukraine beat San Marino, England will have to reach next year’s World Cup via a two-legged playoff.
"We've prepared. We’'e ready. Bring it on," Hodgson told reporters.
With echoes of failing to qualify for Euro 2008, Tuesday's match is arguably Hodgson’s most important yet and the England boss knows the lead up to kickoff will be anything but comfortable.
"I'm a worrier," he added. "Anyone who works in football is a worrier. It won't be my best night's sleep because of all of my waking thoughts are around England versus Poland. It's not good we’ve got to wait until Tuesday evening for it.
"But I have great faith and trust in the players. I couldn't be putting a stronger or more confident bunch of players onto the field. But football is not a science. Things can happen in games you don’t want to happen."
England is unbeaten since losing to Sweden last November.