The Bundesliga club's general manager, Klaus Allofs, reveals that his side contacted Chelsea over the summer about the midfielder's availability and continues to be keen on him.
The 22-year-old Belgian international, who spent last season on loan in the Bundesliga with Werder Bremen, has struggled for opportunities with the London side this season, starting just two of its opening seven Premier League games.
With manager Jose Mourinho previously saying that he was unhappy with the player's performance, Wolfsburg will hope the that lure of first-team football will persuade him to join them.
"We, as a club, have given our signal of interest in the services of Kevin De Bruyne," Allofs told Sky Deutschland. "This was done over the summer when it became obvious that he would be returning to Chelsea.
"Kevin De Bruyne is no first-team regular at this point in time. We will definitely consider what is going on with him."
The midfielder is currently with the Belgium squad in Croatia, where it is preparing for their crucial World Cup qualifier on Friday.