The forward has completed his suspension and returned to Liverpool's starting lineup.
Daniel Sturridge joins the 26-year-old in attack with support from Victor Moses, while captain Steven Gerrard gets the start in midfield along with Lucas Leiva, Jordan Henderson, and Jose Enrique in a new-look 3-4-1-2 formation from Brendan Rodgers.
Summer signings Kolo Toure and Mamadou Sakho form the back line with Martin Skrtel in front of goalkeeper Simon Mignolet.
Wayne Rooney leads out United as captain in the center of an attacking midfield trident flanked by Shinji Kagawa and Nani, with Chicharito Hernandez assuming the lone striker role ahead.
Phil Jones and Ryan Giggs anchor the midfield for David Moyes' side, while Rafael returns from injury to slot into the defense with Jonny Evans, Chris Smalling, and Alex Buttner.
David De Gea takes his usual place in between the pipes for the home side.
Manchester United: De Gea; Rafael, Evans, Smalling, Buttner; Jones, Giggs; Nani, Rooney, Kagawa; Hernandez
Subs: Amos, Fabio, Anderson, Carrick, Zaha, Januzaj, Welbeck
Liverpool: Mignolet; Toure, Sakho, Skrtel; Enrique, Henderson, Lucas, Gerrard; Moses; Suarez, Sturridge
Subs: Jones, Alberto, Aspas, Sterling, Ibe, Kelly, Wisdom