The defender says all players will have to prove themselves to the new manager, and believes that Sir Alex Ferguson's work ethic will be vital for the club's future
Moyes will take over from Sir Alex Ferguson at Old Trafford in July following the 71-year-old's retirement.
And while Ferdinand admits it will be a daunting task for Moyes, he says the players will be aiming to prove themselves to the new manager.
"You've got to prove yourself under the new manager," Ferdinand told The Guardian. "He's going to come in with new ideas, new rules and a new regime. No matter how long we've been here, the likes of Ryan Giggs and myself have been here for many years, we'll be in the same boat instead as people like Danny Welbeck, Phil Jones and Tom Cleverley.
"So we've all got to be wanting to prove ourselves to make sure he thinks we're the right people to start each game. They are massive shoes to fill but he couldn't be walking into a healthier situation. The young players here are hungry and want to win stuff.
"The senior players have won a lot of things but have still got the desire and the work ethic that the manager has instilled into us. I think that's vital for the future of the club."