The former England international first announced his retirement in the summer of 2011, but he returned to the Red Devils' first team just six months later, even after having a testimonial at Old Trafford played against the New York Cosmos.
He immediately became a key cog in Sir Alex Ferguson's team upon his return, but he has struggled with a knee injury in 2013 and has made only three appearances since the turn of the year, of all of which have come in the FA Cup. He was inserted into the starting lineup for Ferguson's final match at Old Trafford on Sunday.
"It's probably not the season I would have liked to have gone out on but the last four months have been quite difficult with injury, with my knee, trying to get back fit again," Scholes told Sky Sports. "I'm totally convinced [this is the right decision]. I was convinced last time, at the time you are, I know now in my head I've gone as far as I possibly can physically. I think this will be the end... again."
Scholes played more than 700 games for Manchester United in all competitions, scoring 155 goals. He also was capped for England 66 times before retiring from international football in 2004.