With Emmanuel Adebayor unable to find the net in the Premier League since New Year's Day and Jermain Defoe sidelined for up to 10 days with a groin injury, the Portuguese tactician appears set to start his star winger up front against the Swiss outfit.
With the Welshman having scored 12 goals in all competitions so far in 2013 (and 22 over the duration of the 2012-13 campaign), Villas-Boas has expressed his confidence in Bale's ability to play in a centre-forward role.
"With his run of form, as a striker he is most effective," Villas-Boas told The Daily Mirror. "He is extremely comfortable playing as a striker. The more he plays there the more he is likely to be helping the team."
Villas-Boas also spoke highly of his side's quarterfinal opponent, citing the reigning Swiss Super League title holder's Champions League experience as a particular danger facing his side.
"Basel have European experience that we don’t have," Villas-Boas said. "They have had tremendous results against United, Sporting and Bayern - teams they have surprised.
"The quarterfinalists are all difficult teams to play, because all eight teams believe they can win the trophy. The key to the game will be the motivation of the teams and the quality of the individuals.
"You have to admit we have superior players but their recent European experience in the Champions League makes them also one of the favorites."