Manchester United and Chelsea could meet in the FA Cup sixth round but will have to negotiate their respective fifth round ties first before a repeat of the 2006-07 final is realized.
Chelsea convincingly beat Brentford 4-0 at Stamford Bridge on Sunday afternoon and will face Middlesbrough at the Riverside Stadium on Feb. 27, while United hosts Reading on Monday night as the club competes on three fronts heading into the final few months of the campaign.
Oldham, the lowest ranked side left in the cup, has to find a way past Everton in its fifth round replay at Goodison Park but will be rewarded with a home tie against Wigan should it do so.
Premier League champion Manchester City faces Barnsley at the Etihad Stadium, while Millwall entertains Blackburn at The Den.
All ties will be played on the weekend of March 9 and 10.
Sixth-round draw in full:
Oldham or Everton v Wigan
Manchester City v Barnsley
Manchester United or Reading v Middlesbrough or Chelsea
Millwall v Blackburn