The recently injured defensive duo will not be risked as Brendan Rodgers looks to freshen up his squad ahead of the key Premier League match against Newcastle United on Sunday.
Liverpool first-team coach Mike Marsh has confirmed that Pepe Reina and Glen Johnson will sit out the Reds' mid-week clash with Swansea City in the Capital One Cup as they continue to recover from respective injuries.
The goalkeeper could only manage a place on the substitutes’ bench in the 2-2 draw against Merseyside rival Everton on Sunday, as back-up stopper Brad Jones continued to deputize in his place as his rehabilitation from a hamstring injury continues.
Johnson, meanwhile, is also set to miss out with a knock he picked up during last Thursday's 1-0 UEFA Europa League win over Russian side Anzhi Makachkala. The right back sat out the weekend derby altogether, with Jose Enrique switching from his preferred left back position to cover, and he will not be rushed back into the side for the Swansea match as a precaution.
"They're both unavailable for the Swansea game. We'll see where they are after that," Marsh told the club's official website.
Despite the injury worries over two of the Reds' most senior individuals, Marsh also revealed how Liverpool came through the derby game without any fresh fitness concerns, but he did admit Brendan Rodgers will largely field a second-string side.
"The boys have come out of it [the derby] well and they're all fit and strong," Marsh added. "One or two are carrying knocks. [Tomorrow is] a chance to rest one or two and give one or two other players a chance to get some game time."