The Frenchman's strike was not only a crucial blow landed in the fight for the title - it also sealed an incredible record of 20 consecutive wins at home, the first time that such a feat has been achieved in the English top flight.
Roberto Mancini has led his troops through a highly successful period, leading the way in the standings for most of the 54 weeks over which they have maintained this astonishing run of form.
It is a record that has seen City blitz 56 goals and concede just eight, a fearsome statistic of which any side in the world would be proud, and Goal.com took it upon itself to relive the brilliance of Mancini's record-breakers at the Etihad Stadium.
Our visual journey begins more than a year ago as the Citizens lined up to face Wigan on March 5, 2011.
One: David Silva sets it all in motion as the Latics are the first victims in a 1-0 win
Two: Adam Johnson's goal is the first of many as Mancini's side demolish Sunderland 5-0
Three: Nigel de Jong scores early on to set City on their way to beating West Ham 2-0
Four: A stroke of luck as Peter Crouch's own goal is the only difference against Tottenham
Five: City rehearses its FA Cup final victory by thumping Stoke 3-0
Six: Sergio Aguero announces himself as Swansea is demolished in 2011-12's opener
Seven: Aguero blitzes all three as Mancini's men down Wigan 3-0
Eight: Jack Rodwell and Everton fight hard before City recovers to win 2-0
Nine: Aston Villa is seen off 4-1 with a touch of the spectacular from Mario Balotelli
10: Edin Dzeko has to fight but makes the scoresheet as Wolves are felled 3-1
11: A rare Micah Richards strike helps end Newcastle's unbeaten league start
12: Norwich cannot outmuscle Yaya Toure, who contributes to a 5-1 hammering
13: The sparkling Silva sneaks City past Arsenal in a lively December meeting
14: Aguero is in top form against Stoke, poaching two of three unanswered goals
15: Joe Hart was not the only City man to enjoy the 3-0 beating of Liverpool
16: Balotelli makes all sorts of headlines as City triumphs over Tottenham in a thrilling 3-2
17: Mancini sees his troops battle through thick snow to overcome Fulham on Feb. 4
18: Aguero is on form once again as lowly Blackburn is dispatched 3-0
19: The ever-inscrutable Super Mario has the final word in a 2-0 win over Bolton
20: Nasri and Tevez combine to seal the record more than a year after the run began