The Gunners manager is adamant that the New York Red Bulls star can make an impact either alongside the Dutchman or out wide.
The Gunners manager believes that, if the balance of the team is right, Van Persie and Henry are more than capable of striking up a partnership.
"They can [play together] as long as the team is balanced," Wenger said. "If it is balanced offensively and defensively then they can. But we are in a structure with two wingers so it is difficult to find the balance. But they can.
"I gave Robin a breather [in the FA Cup against Leeds] because he is under more pressure than anybody else because of his injury history and because he played more games than anybody else in 2011.
"He was always happy when Thierry joined us but what we expect of him now is to continue his goalscoring record he delivered in 2011 and hopefully he'll be ready for another fight.
"It is good because they have a good understanding. It is like having two goalkeepers, [when you have] two strikers when they have a good understanding - which is not always the case because most of the time they are rivals but this is not the case [with Henry and Van Persie]."
Wenger is also toying with the idea of playing Henry out wide when his side make the trip across the border to play Welsh outfit Swansea City on Sunday afternoon.
"He can as well [play out wide] because he still has the reflexes of a winger," Wenger continued.
"When he is on the left side he can still pass people and deliver. But of course it demands a lot of physical effort and it is more suited to a player who is between 20 and 30. But he can still do it. Even physically he had exceptional quality so even if he has dropped a little bit, he is still good. When you are average and drop a little bit you become very average."