Van Persie, 26, the most recent recipient of the Player of the Month award, understands the movement of his team-mates in the fluid system.
"It is because he knows how we play," Wenger revealed on the club's official website.
"The team has played together for four or five years now and everybody knows the movement of each other.
"Van Persie has adapted to our style and is suited to it, like Drogba is suited to the Chelsea style."
Arsenal travel to the Molineux stadium this afternoon to take on Premier League new-boys Wolverhampton Wanderers.
Alan Dawson, Goal.com
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