The Juventus midfielder says the squad is feeling the pressure as it seeks to secure a 'historic' place at the World Cup.
"Of course there is anxiety. It is a fundamental game for us," said Vidal. "We are close to something historic, qualifying twice for the World Cup. We have a very difficult rival, which is Colombia. They're in a little bit of a better position than us but it's a really important game, so we are keeping our enthusiasm up so we play at 100 percent."
Chile goalkeeper and captain Claudio Bravo, meanwhile, is confident his team will handle the big occasion.
"The anxiety is part of this," he said. "We are very accustomed to living in these moments. A qualifying game is much more important than a regular club match."
Despite the prize at stake, Colombia boss Jose Pekerman expects an entertaining encounter against Jorge Sampaoli's men.
"The match should be one of the most exciting in the qualifiers because of the way we and Chile play," he told reporters. "In general, the players are in good form. We have to adapt to what we want to do and we have to be clear when we begin a match and know what type of game we want to play."