The Paris Saint-Germain striker believes la Celeste must treat all of their remaining qualification matches with equal importance if they are to secure their route to Brazil.
Oscar Tabarez's men, who sit fifth in the CONMEBOL standings, have endured a tougher campaign than initially expected.
However, two victories over their South American rivals could potentially propel the Copa America winner into the automatic qualification places and Cavani says the team has the personnel to negotiate both games.
"I don't want to say which match is more important. For Uruguay, every match is a final," he told reporters. "We have the weapons to fight against them. The important thing is not to think about the others, but to win to be closer to our goal.
"We must not have negative thinking. If we lose, we will see how we deal with that, but we are going to jump into the field to win the game. That is the goal of everybody here."
Uruguay travels to Peru on Sept. 6, before hosting Colombia four days later.