The striker believes much has changed since Uruguay tamed its rival in last year's Copa America but is still confident of his side's attack ahead of their World Cup qualifier.
"We're not going through a great [period at] present, and Argentina have improved a lot since we faced them," the 25-year-old told ESPN. "We must use their defensive weaknesses. We realize that we cannot make mistakes at the back, because they will not show us mercy. But we have the potential up front to hurt them."
The match is the first of a World Cup 2014 qualifying doubleheader for Uruguay, which will also travel on Bolivia the following Tuesday. La Celeste currently sit fourth in its qualifying group, two points behind leaders Argentina, adding more significance to the head-to-head matchup.
"It is very important to win both games of this series, so we don't fall behind," Suarez said.