The Netherlands international, who had been linked with Manchester United, will complete a reported 9 million euro move to the Stadio Olimpico on Tuesday
The 22-year-old started all seven of Netherlands' games in Brazil this summer and is now poised to complete a move from Rotterdam to Rome.
“Stefan De Vrij will arrive tonight [Monday] at Fiumicino airport and tomorrow morning [Tuesday] at 8 a.m. will undergo his medical at the Paideia clinic,” the Biancocelesti's director of communications Stefano De Martino told Lazio Style Radio.
“We welcome with joy the best defender at the World Cup. He is an international-level signing.”
Lazio has been looking to strengthen its defense this summer and was left disappointed after being pipped to the signing of Cagliari's Davide Astori by city rival Roma.
However, the Rome side is now set to seal a reported 9 million euro deal for De Vrij, who had also been linked with Premier League outfit Manchester United.