The Spanish club announced the signing of Benfica's Argentine defender on a season-long temporary deal.
The Portuguese giant signed Lopez from Arsenal de Sarandi this summer, but has chosen to send him away from the Estadio da Luz to gain first-team experience.
A statement released on Getafe's official club website read: "We have reached an agreement with Benfica for the transfer of Lisandro Lopez for 2013-14."
Getafe coach Luis Garcia Plaza will hope the Argentina international's arrival will help kick start the club's Liga campaign, which has so far yielded a solitary point from the first three fixtures.
Earlier in the summer Lopez was linked with a host of top European clubs, but Benfica acted first to clinch the signature of the highly-rated defender.