The Primera Division giant has confirmed the capture of the attacking midfielder on a contract until the summer of 2018.
The 21-year-old starlet had also caught the attention of Manchester City, as former Malaga boss Manuel Pellegrini was keen to lure him to the Premier League, but he has opted to continue his career in La Liga instead.
Madrid president Florentino Perez had already revealed earlier in the week that the club was on the verge of signing the gifted youngster and it has now made the deal official.
"Real Madrid and Malaga have reached an agreement over the transfer of Francisco Roman Alarcon Isco, who will sign a five-year contract with the club," a Madrid statement reads. "The player will undergo his medical on July 3 and then be presented to the press at the Santiago Bernabeu."
Isco is a product of the Valencia youth academy, but left Los Che in the summer of 2011 in an attempt to get regular playing time elsewhere. He had since developed into a key player at Malaga and was one of the stars of the Spain U-21 team that was crowned European champion in Israel this summer.