The promising defender is set for a permanent switch to Old Trafford after flying into the country to complete a physical evaluation before international duty.
The Uruguay Under-20 international spent the end of last season on trial at Old Trafford and impressed coaches enough to make a permanent move to the Premier League side. Now, the 20-year-old will become the first signing under the management of David Moyes, who approved the deal, after Varela confirmed he was flying to London in order to complete a medical.
"I will have a medical on Friday, and on Saturday I join the Uruguay Under-20s national team," Varela told Futbol a lo Penarol radio before his departure from Uruguay on Thursday. "I will have to learn English. Rodolfo Catino [Penarol's club treasurer] taught me something. The structure is impressive."
Catino, who traveled with Varela in order to complete the deal on behalf of the club, believes that the promising youngster can settle into life in a new country.
"The deal has been agreed," Catino said. "We now have to discuss some points, but there won't be any percentage regarding any future transfer.
"The deal can be as much as 2.8 million euros. Guille will adapt quickly to Manchester."