The Serie A club is in the market for a new shot-stopper and has pinpointed the 24-year-old Gunners player as a potential target.
The Italian has been propelled into the Gunners' first team this season following injuries to both Wojciech Szczesny and Lukasz Fabianski, and received plaudits for his displays against Manchester City and Liverpool in recent weeks.
After first-choice target Mattia Perin opted to join Pescara on loan from parent club Genoa, Napoli has now pinpointed Mannone as a potential signing.
Mannone's current contract expires in 2014, and confirmed on Saturday that no talk of an extension has currently been broached.
“Neither myself nor anyone from my family or friends have spoken about any deal,” he said. “At the moment I am really happy and just focusing on training and playing well. I am trying to be the No.1 for this club and win trophies. That is my only concern and I would like to make that clear."
Inter is also thought to be showing an interest in the 24-year-old, who Wenger recently confirmed had been available for purchase during the summer - though no club submitted a concrete bid.
"When I sent Mannone to Hull, I watched him every single game and all the reports I had were very positive. I was quite surprised no club went for him because I would have let him go," the Arsenal boss told reporters.