The Portugal international won a treble under the new Spurs coach's management in 2011 and starred at Euro 2012.
The 25-year-old, who worked under the new Spurs coach at Porto during their treble-winning 2010-11 season, impressed for Portugal during this summer's Euro 2012.
Villas-Boas has confirmed that his side is in discussions with several clubs over the sale of Luka Modric and admitted the Croatian could leave White Hart Lane for "the right price" this summer.
The Tottenham boss conceded that Moutinho was a target for his side but was adamant that the Porto midfielder was not his only target.
"He [Moutinho] was one of the most important players at Euro 2012, he had a fantastic tournament, and also he's an important player for Porto," said the recently-appointed manager. "Counting on players of this quality will always be interesting for us.
"It doesn't mean that it's the only target, but if something happened of course he's a player we look on with some interest."
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