Benfica looks to claim the title after losing its past eight European finals, including last year's Europa League decider against Chelsea.
Benfica will try for the eighth time to banish the curse of Bela Guttman when it faces Sevilla in Wednesday's UEFA Europa League final.
Legendary Hungarian Guttman took charge of the Lisbon club from 1959 to 1962, signing Eusebio and leading the club to domestic as well as continental success.
Two Primeira Liga crowns and two European Cups were won in his stint at the helm, but Guttman left the club after a dispute over his pay and is famously said to have decreed that Benfica would not win a European title for another 100 years.
Benfica, which has lost eight European finals since, was beaten in the European Cup final by PSV on penalties in 1988, though last season's 2-1 Europa League showpiece loss to Chelsea may have been the most heartbreaking.
Branislav Ivanovic's 93rd-minute winner dashed Benfica's dreams in a season that also saw it lose the Taca de Portugal final to two late goals, as well as being denied the league title by defeat to Porto in the season's penultimate game.
Rather than lick its wounds, Benfica has responded in fine style this season, winning the Primeira Liga with two games to spare, claiming the Taca de Liga over Rio Ave and reaching the Taca de Portugal final — in which it will face the same opponent.
Center back and captain Luisao, however, is keen for his side to retain its focus as it looks to finally break the club's continental hoodoo.
He told UEFA.com: "It will be very difficult. We are two teams with a shared goal going into this final. It will all come down to one game, and we have great respect for them — we know there are two teams that will be competing in this final."
Juventus Stadium will host the event, with Benfica having denied the stadium's tenants at the semifinal stage on its way to consecutive final appearances in the competition.
Sevilla is the last side to retain the trophy, having succeeded under Juande Ramos in 2006 and 2007.
Unai Emery's men reached Turin in stunning circumstances as Stephane Mbia's 94th-minute goal secured a semifinal victory over Valencia on away goals, having overcome city rival Real Betis in the previous round.
The Andalusian side sold Jesus Navas, Alvaro Negredo and Gary Medel in preseason but has impressed under Emery and will finish in La Liga's top six, as well as looking to secure a European crown.
Striker Kevin Gameiro has replaced Negredo's goals with 21 strikes to his name, but suspects his side will be seen as the underdog in Italy.
He said: "We know it's a great season for Benfica as well. They've had a great campaign, they've won their league, and they knocked Juventus out which was not an easy task, especially in Turin. But it's a one-off game and anything is possible. The most important thing is to give everything and not regret anything at the end — to give everything, to be 100 percent fit and then see what happens."
Jairo Samperio will miss the final for Sevilla due to suspension, while Benfica will not have Lazar Markovic, Enzo Perez and Eduardo Salvio available.
Gameiro's own inclusion is in doubt as he battles a knee injury.