Both sides have been lurking in the shadows of their more well-known city rivals, and now have the opportunity to make history by emerging triumphant in the final of Europe's second-tier competition.
With the final in Hamburg looming on Wednesday evening, Goal.com UK took a look at the Castrol Rankings of the two challengers' potential line-ups to get an insight into what to expect.
And in one of the closest head-to-heads so far, Fulham have the edge player-by-player with a 6-5 victory, but Atleti hold a slender points advantage.
It is at the back that Fulham seem to have the most telling presence, Mark Schwarzer, Brede Hangeland and Paul Konchesky holding sizable advantages over their opposite numbers.
But the midfield is an entirely different story, as influential Portuguese winger Simao's advantage over the rest of the pack proves to be telling. Even Damien Duff's 195-point advantage over Jose Antonio Reyes only reduces the gap.
Up front, former Manchester United hitman Diego Forlan and one of Europe's hottest properties at the moment, Sergio Aguero, combine to ensure that Zoltan Gera and Bobby Zamora stand little chance by comparison. This gap could increase further if the latter is not able to overcome an Achilles injury in time for the final.
Here are the Castrol Rankings in full:
|Fulham by 276pts
|Fulham by 7pts
|Fulham by 47pts
|Atletico by 15pts||Aaron
|Fulham by 74pts||Paul
|Fulham by 195pts
|Atletico by 64pts||Dickson
|Fulham by 11pts
|Atletico by 139pts||Zoltan
|Atletico by 179pts||Bobby
Overall head-to-head score:
Atletico Madrid 5 Fulham 6
Overall points advantage: Atletico by 187
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