Borussia Dortmund duo Robert Lewandowski and Lukasz Piszczek were consigned to a roles as spectators as Poland was pipped to top spot in its section by England, with Ukraine finishing ahead of the Euro 2012 co-host as well.
NO LOVE FOR LEWY | The prolific attacker was unable to guide his nation to Brazil
Furthermore, Real Madrid ace Gareth Bale - the world's most expensive player following his summer transfer from Tottenham - and in-form Arsenal midfielder Aaron Ramsey miss out as Belgium and Croatia proved to be too strong in their qualification section.
Bye bye Bale | Wales was unable to spring a surprise in a group with Belgium and Croatia
The aforementioned five are by no means the only high-profile names from Europe to miss out, though, as the likes of Henrikh Mkhitaryan (Armenia), David Alaba (Austria), Tomas Rosicky (Czech Republic), Christian Eriksen (Denmark), Stevan Jovetic and Mirko Vucinic (both Montenegro), Adrian Mutu (Romania), Branislav Ivanovic (Serbia), Marek Hamsik (Slovakia), Samir Handanovic (Slovenia), Arda Turan (Turkey) and Andriy Yarmolenko (Ukraine) all failed to qualify for the World Cup as well.
Austria is no Bayern | Alaba ended up on the losing side more than he is accustomed to
Although the majority of South American stars did qualify, there are still some interesting omissions from next summer, with Oscar Cardozo (Paraguay), Jefferson Farfan, Claudio Pizarro (both Peru) and Juan Arango (Venezuela) perhaps the most noteworthy absentees.
Arango anger | The gifted midfielder is unlikely to ever feature at the World Cup
In Africa, meanwhile, Senegal stars Papiss Cisse and Demba Ba will not be at next year's tournament either after Cote d'Ivoire proved to be too much of an obstacle in the decisive playoff.
Sorry Senegal | Chelsea attacker Demba Ba won't be on the plane to Brazil
Additionally, Egypt's elimination means the World Cup will be deprived of the exciting talents of Mohamed Salah and Mohamed Aboutrika.
Other high-profile absentees from Africa include Younes Belhanda and Mehdi Benatia (both Morocco), Emmanuel Adebayor (Togo), Youssef Msakni (Tunisia) and Victor Wanyama (Kenya).