La Roja are still reeling from last week's 5-1 hammering that left them facing an uphill struggle to qualify from Group B.
The new Chelsea signing has warned his teammates they must take their chances if they are to get their campaign to retain their world title back on track.
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"We know what we're playing for and against whom,” the 27-year-old told Movistar. “It's up to us, we have to dominate the match. We know there will be times when we will have to resist and when we have chances, we will have to take them.”
"The most important thing is to win, and then if we can score more than one goal, better. Then we'll have to play Australia".
La Roja’s humbling at the hands of the 2010 runner up has led to questions over whether their time at the top of the game is over, and has seen calls for a complete overhaul of the side.
However, Fabregas insists there is no need for wholesale changes.
"The boss will have his ideas about what he has to change and what he will leave the same, but I don't think there will be a huge amount of changes because I think this side has shown how good it is," he said.
"We are positive, even though it has been hard. I see the side fully focused on what they have to do, training well, with the right mentality. We have to win and get the three points, which are vital".
Following the 2010 world title and back-to-back European championships in 2008 and 2012, Spain is aiming to become the first national team to win four major international tournaments in a row.