The Albiceleste last triumphed in the competition way back in 1986 and have failed to win the Copa America since 1993.
The Barcelona star has acknowledged that going so long without silverware is unacceptable for Argentina and is determined to put that right over the next month.
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"In Argentina, we have not won a major trophy for the last 20 years or so," he told the Times of India. "We were the hosts of the Copa in 2011 but failed to win it. For a proud football-playing nation, 20 years is too long without winning a major trophy. So, we all are eager to do something in Brazil.
"Who doesn't want to win a World Cup for his country? I am an Argentine and we have won two World Cups, the last one being 28 years ago, before I was even born. I have not seen the celebrations of the fans in our streets after winning the most coveted prize in football. I've only heard about it. To witness it would be very special. But to do so, we need to win the trophy, which is the most difficult job under the sun for a football team."
The only time Argentina can meet Brazil is in the final but Messi is refusing to think about getting that far just yet, arguing that Argentina's group, including Bosnia-Herzegovina, Iran and Nigeria, poses threats of its own.
"We are not obliged to think as far [as the final]. In Barcelona, we always say think only of the next game. That is the best approach for any team. At the moment, we are only concentrating on our first-round opponents, especially on Bosnia-Herzegovina, who we will open our account against at the World Cup in Rio de Janeiro.
"An easy match in the World Cup? Are you kidding? Bosnia might be making their debut but we know they are a strong and disciplined European team with stars like Edin Dzeko having inspired them to qualify for Brazil."