The 31-year-old attacker has been struggling with a back problem in recent weeks, and Didier Deschamps, the head coach of Les Bleus, confirmed during a press conference on Friday afternoon that the Ballon d’Or nominee’s situation has worsened.
“This morning Ribery stopped during a run. Now, he cannot train,” Deschamps explained. “Tests have confirmed a worsening of the situation. He cannot play.
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"We must stay ambitious, but of course we would have been stronger with Ribery at 100 percent."
Ribery’s injury was the second blow that France suffered on Friday, as Clement Grenier aggravated a thigh problem, which had plagued him in the latter part of the season, leading to the Olympique Lyonnais playmaker also withdrawing from the squad.
Deschamps revealed that he has already called up two replacements in the form of Montpellier’s Remy Cabella and Southampton’s uncapped Morgan Schneiderlin.
The loss of Ribery, however, will be seen as a significant blow to France’s hopes of World Cup success, as the Bayern star was the team's most experienced player available with 81 appearances.
Antoine Griezmann of Real Sociedad is widely expected to take the Bayern star's place in Deschamps’ starting XI.