The 31-year-old midfielder said he likely can't see himself playing in the 2018 World Cup and that he's not guaranteed a spot in this summer's tournament.
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"It's hard for me to imagine, sitting here, that I'll be able to walk in four years, much less play soccer," Donovan told ESPNFC on Monday. "So I would guess that this is my last chance of making a World Cup."
The 2014 World Cup will be the fourth for Donovan, who is widely considered one of the greatest players in U.S. soccer history.
Last year, Donovan took a short break away from the game and was not called up for qualifiers in early 2013. Although it's almost a guarantee that he'll make the World Cup roster, the LA Galaxy man insists it will be tough to earn a spot with such a deep player pool.
"Personally, I realize very clearly the competition involved," he said. "More likely than not I will be used as a midfielder in some way, and there's a lot of midfielders pushing for a few spots in the wide positions."